Center for Molecular and Genomic Imaging


Available PET Tracers

PET Radiotracers Available at CMGI

PET uses 18F- or 11C-substituted analogs of small molecules that are involved in biochemical processes, to elucidate image tissue perfusion, metabolism, drug/receptor interactions, and gene expression in vivo. For example, [18F]Fluorodeoxyglucose, an analog of glucose, is used to image areas of high metabolism, such as rapidly proliferating tumors. Targeting molecules may also be covalently conjugated to a metal binding chelating agent, such as TETA or desferrioxamine, to be radiolabeled with 64Cu or 89Zr, respectively, for PET imaging.

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[18F]Fluoride

[18F]Fluoride in aqueous solution is used primarily to image bone and therefore can provide information on features of the skeleton.

Half life 110 minutes; available daily.

[18F]FDG

[18F]Fluorodeoxyglucose, one of the most commonly used PET tracers, is used to measure tissue glucose metabolism. It has important diagnostic and research applications in oncology, neurology, and cardiology.

Half life 110 minutes; available daily.

[18F]FHBG

9-(4-[18F]Fluoro-3-hydroxymethylbutyl) guanine is a reporter probe for the herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene, which is transfected into malignant cells in experimental suicide gene therapy.

Half life 110 minutes; available daily.

[18F]FLT

[18F]Fluorothymidine is a marker for cell proliferation that is more selective for tumor imaging than [18F]FDG.

Half life 110 minutes; available daily.

[18F]FMISO

[18F]Fluoromisonidazole is used for the detection of hypoxia in  tumors, myocardial infarcts, or cerebral ischemia.

Half life 110 minutes; available daily.

[11C]Raclopride

[11C]Raclopride is a widely used PET tracer for measurement of D2 dopamine receptor binding characteristics.

Half life 20 minutes; available daily.

[11C]SCH23390

[11C]SCH23390 is used to measure D1 dopamine receptor binding characteristics.

Half life 20 minutes; available daily.

[11C]PK11195

[11C]PK11195 is used to measure microglial activation, associated with various neurodegenerative and neuroinflammatory deseases.

Half life 20 minutes; available daily.

[64Cu]Cu-PTSM

[64Cu]Cu-pyruvaldehyde-bis[N4-methylthiosemicarbazone] is a tracer for blood flow, hypoxia, and cell binding studies.

Half life 12.7 hours; available every two weeks. Please inquire for specific dates.

64Cu- and 89Zr-labeled proteins, peptides, and high MW probes (above)

Relatively long-lived 64Cu (half life 12.7 hours) and 89Zr (78.4 hours) are well matched to the longer uptake and residence times of higher molecular weight probes such as antibodies, peptides, and nanoparticles.

[64Cu]Cu-TETA-conjugates (shown):The molecular probe is conjugated to the chelating (metal binding) agent TETA, which binds 64Cu.

Half life 12.7 hours; available every two weeks. Please inquire for specific dates.

[89Zr]Zr-desferal-conjugates The molecular probe is conjugated to the chelating agent desferrioxamine, which binds 89Zr.

Half life 78.4 hours; available weekly.

Note: CMGI Radiochemistry can conjugate a chelating agent such as TETA or desferrioxamine to a client-supplied molecular probe as a custom synthesis; or the client may provide a chelate-conjugated probe.

Novel Radiochemistry and Custom Synthesis

4-[18F]fluorobenzoic acid (FBA) and 2-[18F]fluoropropionic acid (FPA) are used as building blocks for the synthesis of complex molecules such as [18F]-fluoropaclitaxel and as a prosthetic groups for the labeling of peptides and proteins. The synthesis of FBA has been automated.

Peptides may be site-specifically radiolabeled in the solid phase with 18F via FBA or FPA. In cases where solution-phase labeling is preferred, Cu catalyzed 1,3-dipolar Huigen’s cycloaddition (“click” chemistry) is used. Peptides may also be conjugated to a chelating (metal binding) agent for radiolabeling with 64Cu or 89Zr.

Solid phase peptide labeling using
4-[18F]fluorobenzoic acid (FBA).

“Click” chemistry for radiolabeling of
peptides with [18F]fluoroalkynes.