Magnetic resonance imaging (MRI) provides excellent soft-tissue contrast, allowing high-resolution anatomical imaging. More recently, the development of molecular-targeted contrast agents now allows high-resolution molecular imaging, which has increasingly been used for multimodal imaging in combination with PET to meld in a single image the exceptional anatomical resolution of MRI with the powerful functional imaging ability of PET. Research applications of MRI include stem cell and pathophysiologic imaging, including atherosclerosis, as well as volumetric brain imaging.
A new Bruker BioSpec 7T horizontal bore system designed specifically for small animal imaging has been commissioned at CMGI (July 2010). Dedicated animal beds for mice (up to 35 g) and rats (up to 400 g) incorporate a circulating warm-water circuit to maintain body temperature, and can be fitted with a nose cone for anesthetic inhalation. A stereotactic frame is integrated into the animal beds to provide reproducible positioning of the same animal over multiple imaging sessions. Both cardiac and respiratory gating are available and may enhance image quality for some imaging protocols. Of special interest is the potential for PET/MRI multimodality imaging. A second generation PET insert being developed in Dr. Cherry’s laboratory will be fitted within the bore to obtain simultaneous data acquisition and a co-registered PET/MRI image.
The following gradient/shim systems and coils are available:
The updated ParaVision 5.1 software package for acquisition and processing allows 2D or 3D imaging with processing features that include magnification, ROI analysis and geometrical measurement. Three CMGI staff members are trained to use the system and can provide assisted MRI scans upon request. In some cases, after sufficient technical and safety training, unassisted scanning by PIs or their staff will also be available.
Please inquire (firstname.lastname@example.org) for further information.
|PET||Inveon DPET||Siemens||~ 1.5 mm|
|PET||Focus 120||Siemens||~ 1.5 mm|
|PET||Primate 4||Siemens||~ 2.0 mm|
|PET||microPET II||Custom-built||~ 1 mm|
|SPECT||Inveon||Siemens||~ 0.5 – 3 mm|
|CT||Inveon||Siemens||~ 50 – 150 µm|
|MRI||Biospec 7T||Bruker||~ 100 – 250 µm|
|Ultrasound||Sequoia||Siemens||~ 100 – 500 µm|
|Optical||Maestro 2||CRi (Caliper)||~ 1 – 5 mm|
|Optical||IVIS 100||Xenogen (Caliper)||~ 1 – 5 mm|
|Autoradiography||Storm 860||Amersham Biosciences||~ 50 – 100 µm|