X-ray computed tomography (CT) provides high resolution 3-D anatomical imaging. It is particularly useful for imaging bone and fat, but can also provide capabilities for soft-tissue and vascular imaging by the use of suitable contrast agents. Animals can be scanned by PET or SPECT and CT in the same session and the images coregistered to give a single image combining functional PET/SPECT with anatomical CT data.
Our InveonMM CT module is a powerful and versatile tool for x-ray computed tomography of small animals. The configuration of this module includes a variable-focus x-ray source that provides a maximum spatial resolution of 50 μm in microfocus mode. In addition, its 165 mm detector allows a large 10 cm x 10 cm field of view (FOV) that can be cropped as desired to match the dimensions of the animal. Both cardiac and respiratory gating are supported, which can improve resolution during in vivo imaging of the heart and lungs, for example. When used for dual-modality imaging with SPECT or PET, the coregistered images display the functional information of SPECT or PET with the anatomical detail of CT in a single image. A CT acquisition can also be used for attenuation correction of the SPECT or PET image acquired during the same imaging session.
|PET||Inveon DPET||Siemens||~ 1.5 mm|
|PET||Focus 120||Siemens||~ 1.5 mm|
|PET||Primate 4||Siemens||~ 2.0 mm|
|PET||microPET II||Custom-built||~ 1 mm|
|SPECT||Inveon||Siemens||~ 0.5 – 3 mm|
|CT||Inveon||Siemens||~ 50 – 150 µm|
|MRI||Biospec 7T||Bruker||~ 100 – 250 µm|
|Ultrasound||Sequoia||Siemens||~ 100 – 500 µm|
|Optical||Maestro 2||CRi (Caliper)||~ 1 – 5 mm|
|Optical||IVIS 100||Xenogen (Caliper)||~ 1 – 5 mm|
|Autoradiography||Storm 860||Amersham Biosciences||~ 50 – 100 µm|