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 Ultrasound imaging relies on the transmission of ultrasound waves through tissues and the acquisition of reflections from structures in the acoustical pathway. It has been used routinely to assess blood flow, cardiac function, fetal development, and to a more limited degree, tumor development. Small animal imaging utilizes high frequency probes that improve resolution at the price of shorter depth of penetration. The development of new techniques using targeted contrast microbubbles or nanoparticles allow real-time imaging of cellular and molecular events. Applications include detection of inflammatory disorders, targeted gene and drug delivery, and oncology research.
A Siemens ACUSON Sequoia 512 imaging system with a 15L8 transducer (15-8 MHz) is available in the CMGI for ultrasound imaging. The Sequoia 512 supports contrast agent imaging, color flow and Doppler. Peripherals include B/W and color printers, and a physiology module for cardiac gating.
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MODALITY
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MODEL
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MANUFACTURER
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RESOLUTION
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| PET |
Focus 20 |
Siemens |
~1.3mm |
| PET |
P4 |
Siemens |
~1.8mm |
| PET |
microPETI |
Custom-built |
~1.8mm |
| SPECT |
microSPECT |
Siemens |
~1mm |
| CT |
microCAT II |
Siemens |
25-150 um |
| CT |
microCT |
Custom-built |
~ 300um |
| MRI |
Biospec 7T |
Bruker |
50-250 um |
| Ultrasound |
Sequoia |
Siemens |
~ 120 um |
| Optical |
IVIS 100 |
Xenogen |
~ 2mm |
| Autoradiography |
Storm 860 |
Amersham Biosciences |
50-100 um |
For additional information:
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Coatney RW. Ultrasound imaging: principles and applications in rodent research. ILAR J; 42:233-47, 2001.
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Cherry SR. In vivo molecular and genomic imaging: new challenges for imaging physics. Phys Med Biol; 49:R13-48, 2004.
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Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng; 9:415-47, 2007.
- Borden, MA, Zhang H, Gillies RJ, Dayton PA, Ferrara KW. A stimulus-responsive contrast agent for ultrasound molecular imaging. Biomaterials; 29:597-606, 2008.
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