Center for Molecular and Genomic Imaging


Publications

Beginning January, 2009, links to the publications are provided. Availability of articles may depend on your institution.

Wolf ZT, Leslie EJ, Arzi B, et al. A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. Barsh GS, ed. PLoS Genet. 2014;10(4):e1004257. doi:10.1371/journal.pgen.1004257.s005.

Popova OP, Jenniskens P, Emel’yanenko V et al. Chelyabinsk airburst, damage assessment, meteorite recovery, and characterization. Science 2013. Nov;342:1069-73.

Hausner SH, Bauer N, Sutcliffe JL. In vitro and in vivo evaluation of the effects of aluminum [(18)F]fluoride radiolabeling on an integrin αvβ6-specific peptide. Nucl Med Biol. 2014 Jan;41(1):43-50. Epub 2013 Oct 8.

Thorsen F, Fite B, Mahakian LM, Seo JW, Qin S, Harrison V, Johnson S, Ingham E, Caskey C, Sundstrøm T, Meade TJ, Harter PN, Skaftnesmo KO, Ferrara KW. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. J Control Release. 2013 Oct 29;172(3):812-822. [Epub ahead of print]

Tarantal AF, Lee CC, Kukis DL, Cherry SR. Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. PLoS One. 2013 Oct 3;8(10):e7714

Kim MH, Gorouhi F, Ramirez S, Granick JL, Byrne BA, Soulika AM, Simon SI, Isseroff RR. Catecholamine Stress Alters Neutrophil Trafficking and Impairs Wound Healing by β2-Adrenergic Receptor-Mediated Upregulation of IL-6. J Invest Dermatol. 2013 Oct 11. [Epub ahead of print]

Mahakian LM, Farwell DG, Zhang H, Seo JW, Poirier B, Tinling SP, Afify AM, Haynam EM, Shaye D, Ferrara KW. Comparison of PET Imaging with 64Cu-Liposomes and 18F-FDG in the 7,12-Dimethylbenz[a]anthracene (DMBA)-Induced Hamster Buccal Pouch Model of Oral Dysplasia and Squamous Cell Carcinoma. Mol Imaging Biol. 2013 Sep 10. [Epub ahead of print]

Kheirolomoom A, Lai CY, Tam SM, Mahakian LM, Ingham ES, Watson KD, Ferrara KW. Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia. J Control Release. 2013 Nov 28;172(1):266-73. Epub 2013 Aug 28.

Granick JL, Falahee PC, Dahmubed D, Borjesson DL, Miller LS, Simon SI. Staphylococcus aureus recognition by hematopoietic stem and progenitor cells via TLR2/MyD88/PGE2 stimulates granulopoiesis in wounds. Blood. 2013 Sep 5;122(10):1770-8. Epub 2013 Jul 18.

Wong AW, Ormsby E, Zhang H, Seo JW, Mahakian LM, Caskey CF, Ferrara KW. A comparison of image contrast with (64)Cu-labeled long circulating liposomes and (18)F-FDG in a murine model of mammary carcinoma. Am J Nucl Med Mol Imaging. 2013;3(1):32-43. Epub 2013 Jan 5.

Hausner SH, Carpenter RD, Bauer N, Sutcliffe JL. Evaluation of an integrin αvβ6-specific peptide labeled with [18F]fluorine by copper-free, strain-promoted click chemistry. Nucl Med Biol. 2013 Feb;40(2):233-9. Epub 2012 Dec 21.

Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S. Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging. PLoS One. 2012;7(9):e45116, Epub 2012 Sep 17.

White JB, Hausner SH, Carpenter RD, Sutcliffe JL. Optimization of the solid-phase synthesis of [18F] radiolabeled peptides for positron emission tomography. Appl Radiat Isot. 2012 Dec;70(12):2720-9. Epub 2012 Aug 24.

Zhang H, Li N, Sirish P, Mahakian L, Ingham E, Curry FR, Yamada S, Chiamvimonvat N, Ferrara KW. The cargo of CRPPR-conjugated liposomes crosses the intact murine cardiac endothelium. J Control Release. 2012 Oct 10;163(1):10-7. Epub 2012 Jul 7.

Xiao W, Luo J, Jain T, Riggs JW, Tseng HP, Henderson PT, Cherry SR, Rowland D, Lam KS. Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer. Int J Nanomedicine. 2012;7:1587-97. Epub 2012 Mar 27.

Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ. Periocular and intra-articular injection of canine adipose-derived mesenchymal stem cells: an in vivo imaging and migration study. J Ocul Pharmacol Ther. 2012 Jun;28(3):307-17. Epub 2011 Dec 16.

Golub MS, Hogrefe CE, Unger EL.  Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infants.  Genes Brain Behav; 11(3):278-90, 2012.  Epub 2012 Mar 13

Watson KD, Lai CY, Qin S, Kruse DE, Lin YC, Seo JW, Cardiff RD, Mahakian LM, Beegle J, Ingham ES, Curry FR, Reed RK, Ferrara KW.  Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors.  Cancer Res; 72(6):1485-93, 2012. Epub 2012 Jan 26.

Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ.  Periocular and Intra-Articular Injection of Canine Adipose-Derived Mesenchymal Stem Cells: An In Vivo Imaging and Migration Study. J Ocul Pharmacol Ther.  2011 Dec 16. [Epub ahead of print]

Li C, Yang Y, Mitchell GS, Cherry SR.  Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system.  J Nucl Med; 52(8):1268-75, 2011.

Aweda TA, Eskandari V, Kukis DL, Boucher DL, Marquez BV, Beck HE, Mitchell GS, Cherry SR, Meares CF.  New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation.  Bioconjug Chem. 2011 Jul 22. [Epub ahead of print]

Tu C, Ng TS, Sohi HK, Palko HA, House A, Jacobs RE, Louie AY.  Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques. Biomaterials; 32(29):7209-16, 2011. Epub 2011 Jul 13.

Tarantal AF, Lee CC, Batchelder CA, Christensen JE, Prater D, Cherry SR.  Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal Rhesus monkeys. Mol Imaging Biol. 2011 Apr 9. [Epub ahead of print]

Hamzah J, Kotamraju VR, Seo JW, Agemy L, Fogal V, Mahakian LM, Peters D, Roth L, Gagnon MK, Ferrara KW, Ruoslahti E.  Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A; 108(17):7154-9, 2011. Epub 2011 Apr 11.

Zhou P, Lessa N, Estrada DC, Severson EB, Lingala S, Zern MA, Nolta JA, Wu J.  Decellularized liver matrix as a carrier for the transplantation of human fetal and primary hepatocytes in mice. Liver Transpl. 17:418-27, 2011.

Andreozzi E, Seo JW, Ferrara K, Louie A.  Novel method to label solid lipid nanoparticles with 64Cu for positron emission tomography imaging.  Bioconjug Chem; 22(4):808-18, 2011. Epub 2011 Mar 9.

Seo JW, Qin S, Mahakian LM, Watson KD, Kheirolomoom A, Ferrara KW.  Positron emission tomography imaging of the stability of Cu-64 labeled dipalmitoyl and distearoyl lipids in liposomes. J Control Release; 151(1):28-34, 2011. Epub 2011 Jan 15.

Tu C, Ma X, House A, Kauzlarich SM, Louie AY.  PET imaging and biodistribution of silicon quantum dots in mice. ACS Med Chem Lett; 2(4):285-288, 2011.

Kim MH, Granick JL, Kwok C, Walker NJ, Borjesson DL, Curry FR, Miller LS, Simon SI. Neutrophil survival and c-kit+-progenitor proliferation in Staphylococus aureus-infected skin wounds promote resolution. Blood; 117(12):3343-52, 2011. Epub 2011 Jan 28.

Anderson CR, Hu X, Zhang H, Tlaxca J, Declèves AE, Houghtaling R, Sharma K, Lawrence M, Ferrara KW, Rychak JJ.  Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent.  Invest Radiol; 46(4):215-24, 2011.

Hu-Lowe DD, Chen E, Zhang L, Watson KD, Mancuso P, Lappin P, Wickman G, Chen JH, Wang J, Jiang X, Amundson K, Simon R, Erbersdobler A, Bergqvist S, Feng Z, Swanson TA, Simmons BH, Lippincott J, Casperson GF, Levin WJ, Stampino CG, Shalinsky DR, Ferrara KW, Fiedler W, Bertolini F.  Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies.  Cancer Res; 71(4): 1362-73, 2011. Epub 2011 Jan 6.

Rygh CB, Qin S, Seo JW, Mahakian LM, Zhang H, Adamson R, Chen JQ, Borowsky AD, Cardiff RD, Reed RK, Curry FR, Ferrara KW. Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET.  Clin Cancer Res; 17(3):550-9, 2011.  Epub 2010 Nov 24.

Jarrett BR, Correa C, Ma KL, Louie AY.  In vivo mapping of vascular inflammation using multimodal imaging.  PLoS One; 5(10):e13254. 2010.

Kheirolomoom A, Mahakian LM, Lai CY, Lindfors HA, Seo JW, Paoli EE, Watson KD, Haynam EM, Ingham ES, Xing L, Cheng RH, Borowsky AD, Cardiff RD, Ferrara KW.  Copper-Doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity.  Mol Pharm; 7(6):1948-58, 2010.

Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK.  Small particles disrupt postnatal airway development.  J Appl Physiol; 109(4):1115-24., 2010.   Epub 2010 Jul 15.

Seo JW, Mahakian LM, Kheirolomoom A, Zhang H, Meares CF, Ferdani R, Anderson CJ, Ferrara KW.  Liposomal Cu-64 labeling method using bifunctional chelators: poly(ethylene glycol) spacer and chelator effects.  Bioconjug Chem; 21(7):1206-15, 2010.

Li C, Mitchell GS, Cherry SR. Cerenkov luminescence tomography for small-animal imaging. Opt Lett;35(7):1109-11, 2010.

Kruse DE, Lai CY, Stephens DN, Sutcliffe P, Paoli EE, Barnes SH, Ferrara KW. Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. IEEE Trans Biomed Eng; 57(1):155-66, 2010.

Palko HA, Fung JY, Louie AY. Positron emission tomography: A novel technique for investigating the biodistribution and transport of nanoparticles. Inhal Toxicol; 22(8):657-68, 2010. Epub 2010 April 7.

Paoli EE, Kruse DE, Seo JW, Zhang H, Kheirolomoom A, Watson KD, Chiu P, Stahlberg H, Ferrara KW. An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation. J Control Release; 143(1):13-22, 2010. Epub 2009 Dec 16.

Gagnon MK, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL. High-throughput in vivo screening of targeted molecular imaging agents. Proc Natl Acad Sci U S A; 106(42):17904-9, 2009. Epub 2009 Oct 7.

Li C, Wang G, Qi J, Cherry SR. Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors. Opt Lett; 34(19):2933-5, 2009.

Kheirolomoom A, Kruse DE, Qin S, Watson KE, Lai CY, Young LJ, Cardiff RD, Ferrara KW. Enhanced in vivo bioluminescence imaging using liposomal luciferin delivery system. J Control Release;141(2):128-36, 2010. Epub 2009 Sep 11.

Qin S, Seo JW, Zhang H, Qi J, Curry FR, Ferrara KW. An imaging-driven model for liposomal stability and circulation. Mol Pharm; 7(1):12-21, 2010. Epub 2009 Aug 28.

Robertson R, Germanos MS, Li C, Mitchell GS, Cherry SR, Silva MD. Optical imaging of Cerenkov light generation from positron-emitting radiotracers. Phys Med Biol; 54(16):N355-65, 2009.

Ferrara KW, Borden MA, Zhang H. Lipid-shelled vehicles: Engineering for ultrasound molecular imaging and drug delivery. Acc Chem Res. Epub 2009 Jun 25.

Hausner SH, Abbey CK, Bold RJ, Gagnon MK, Marik J, Marshall JF, Stanecki CE,Sutcliffe JL. Targeted in vivo imaging of integrin ανβ6 with an improved radiotracer and its relevance in a pancreatic tumor model. Cancer Res. Epub 2009 Jun 23.

Li C, Mitchell GS, Dutta J, Ahn S, Leahy RM, Cherry SR. A three-dimensional multispectral fluorescence optical tomography imaging system for small animals based on a conical mirror design. Opt Express; 17(9):7571-85, 2009.

Denardo SJ, Liu R, Albrecht H, Natarajan A, Sutcliffe JL, Anderson C, Peng L, Ferdani R, Cherry SR, Lam KS. 111In-LLP2A-DOTA polyethylene glycol-targeting α4β1 integrin: Comparative pharmacokinetics for imaging and therapy of lymphoid malignancies. J Nucl Med; 50(4):625-34, 2009. Epub 2009 Mar 16.

Leu A, Stieger SM, Dayton P, Ferrara KW, Leach JK. Angiogenic response to bioactive glass promotes bone healing in an irradiated calvarial defect. Tissue Eng Part A; 15(4):877-85, 2009.

Kim MH, Curry FR, Simon SI. Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am J Physiol Cell Physiol; 296(4):C848-56, 2009. Epub 2009 Jan 28.

Hausner SH, Kukis DL, Gagnon MK, Stanecki CE, Ferdani R, Marshall JF, Anderson CJ, Sutcliffe JL. Evaluation of [64Cu]Cu-DOTA and [64Cu]Cu-CB-TE2A chelates for targeted positron emission tomography with an ανβ6-specific peptide. Mol Imaging; 8(2):111-21, 2009.

Martin SM, O’Donnell RT, Kukis DL, Abbey CK, McKnight H, Sutcliffe JL, Tuscano JM. Imaging and pharmacokinetics of 64Cu-DOTA-HB22.7 administered by intravenous, intraperitoneal, or subcutaneous injection to mice bearing non-Hodgkin’s lymphoma xenografts. Mol Imaging Biol; 11(2):79-87, 2009; Epub 2008 Oct 24.

Mitchell GS, Cherry SR. A high-sensitivity small animal SPECT system. Phys Med Biol; 54(5):1291-305, 2009; Epub 2009 Feb 3.

Seo JW, Zhang H, Kukis DL, Meares CF, Ferrara KW. A novel method to label preformed liposomes with 64Cu for positron emission tomography (PET) imaging. Bioconjugate Chem; 19:2577-84, 2008.

Jarrett BR, Gustaffsson B, Kukis DL, Louie AY. Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging. Bioconjug Chem; 19(7):1496-504, 2008; Epub 2008 Jun 26.

Tartis MS, Kruse DE, Zheng H, Zhang H, Kheirolomoom A, Marik J, Ferrara KW. Dynamic microPET imaging of ultrasound contrast agents and lipid delivery. J Control Release; 131:160-6, 2008.

Hausner SV, Marik J, Gagnon MKJ, Sutcliffe JL. In vivo positron emission tomography (PET) imaging with an αVβ6 specific peptide radiolabeled using 18F-”Click” chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides. J Med Chem; 51(19):5901-4, 2008.

Kruse DE, Mackanos MA, O’Connell-Rodwell CE, Contag CH, Ferrara KW. Short-duration-focused ultrasound stimulation of Hsp70 expression in vivo. Phys Med Biol; 53:3631-60, 2008.

Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Jacobs RE, Cherry SR.  Simultaneous in vivo positron emission tomography and magnetic resonance imaging.  PNAS; 105(10):3705-10, 2008.

Huang J, Lee CC, Sutcliffe JL, Cherry SR, Tarantal AF. Radiolabeling Rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging. Mol Imaging 7(1):1-11, 2008.

Choi MS, Catana AM, Wu J, Kim YS, Yoon SJ, Borowsky AD, Gambhir SS, Gupta S, Zern MA. Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice. Cell Transplant; 17:899-909, 2008.

Lee D, Park SS, Ban-Weiss GA, Fanucchi MV, Plopper CG, Wexler AS. Bifurcation model for characterization of pulmonary architecture. Anat Rec (Hoboken); 291(4):379-89, 2008

Kim M-H, Liu W, Borjesson DL, Curry F-R E, Miller LS, Cheung AL, Liu F-T, Isseroff RR, Simon SI. Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol; 128:1812-20, 2008.

Zhang H, Kusunose J, Kheirolomoom A, Seo JW, Qi J, Watson KD, Lindfors HA, Ruoslahti E, Sutcliffe JL, Ferrara KW. Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model. Biomaterials; 29:1976-88, 2008.

Stieger SM, Dayton PA, Borden MA, Caskey CF, Griffey SM, Wisner ER, Ferrara KW. Imaging of angiogenesis using CadenceTM contrast pulse sequencing and targeted contrast agents. Contrast Media Mol Imaging; 3:9-18, 2008.

Machado CJ, Snyder AZ, Cherry SR, Lavenex P, Amaral DG. Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: A microPET imaging study. Neuroimage; 39:832-46, 2007.

Marik J, Tartis MS, Zhang H, Fung JY, Kheirolomoom A, Sutcliffe JL, Ferrara KW. Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP). Nucl Med Biol; 34:165-71, 2007.

Aina OH, Liu R, Sutcliffe JL, Marik J, Pan C-X, Lam KS. From combinatorial chemistry to cancer-targeting peptides. Mol Pharm; 4:631-51, 2007.

Bales KL, Mason WA, Catana C, Cherry SR, Mendoza SP. Neural correlates of pair-bonding in a monogamous primate. Brain Res; 1184:245-53, 2007.

Vogel CFA, Li W, Sciullo E, Newman J, Hammock B, Reader JR, Tuscano J, Matsumura F. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am J Pathol; 171(5):1538-48, 2007.

DeNardo, GL, Natarajan A, Hok S, Perkins J, Cosman M, DeNardo SJ, Lightstone FC, Mirick GR, Miers LA, Balhorn RL. Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma. J Nucl Med; 48:1338-47, 2007.

Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL. Use of a peptide derived from foot and mouth disease virus (FMDV) for the non-invasive imaging of human cancer: Generation and evaluation of [18F]FBA-A20FMDV2 for in vivo imaging of integrin xvx6 expression with Positron Emission Tomography. Cancer Res; 67:7833-40, 2007.

Liang H, Yang Y, Yang K, Wu Y, Boone JM, Cherry SR. A microPET/CT system for in vivo small animal imaging. Phys Med Biol ; 52:3881-94, 2007.

Cherry SR. The 2006 Henry N. Wagner lecture: Of mice and men (and positrons) – Advances in PET imaging technology. J Nucl Med; 47:1735-45, 2006.

Abbey CK, Borowsky AD, Gregg JP, Cardiff RD, Cherry SR. Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography. J Mammary Gland Biol Neoplasia; 11:137-49, 2006.

Catana C, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Cherry SR. Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J Nucl Med; 47:968-76, 2006.

Gustafsson B, Youens S, Louie AY. Development of contrast agents targeted to macrophage scavenger receptors for MRI of vascular inflammation. Bioconjug Chem; 17(2):538-47, 2006.

Namba R, Young LJT, Abbey CK, Kim L, Damonte P, Borowsky AD, Qi J, Tepper CG, MacLeod CL, Cardiff RD, Gregg JP. Rapamycin inhibits growth of premalignant and malignant lesions in a mouse model of ductal carcinoma in situ. Clin Cancer Res; 12:2613-21, 2006.

Tarantal AF, Lee CC, Jimenez DF, Cherry SR. Fetal gene transfer using lentiviral vectors: In vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys. Hum Gene Ther; 17:1254-61, 2006.

Yang YY, Rendig S, Siegel S, Newport DF, Cherry SR. Cardiac PET imaging in mice with simultaneous cardiac and respiratory gating. Phys Med Biol ; 50: 2979-89, 2005.

Yang Y, Tai Y-C, Siegel S, Newport DF, Bai B, Li Q, Leahy RM, Cherry SR. Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging. Phys Med Biol; 49:2527-45, 2004.

Abbey CK, Borowsky AD, McGoldrick ET, Gregg JP, Maglione JE, Cardiff RD, Cherry SR. In vivo PET imaging of progression and transformation in a mouse model of mammary neoplasia. Proc Natl Acad USA; 101:11438-443, 2004.